半岛bd体育手机客户端 说明
一般描述
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50~50 ?M). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50= 50 mM and 64 mM, respectively).
包装
10 mg in Glass bottle
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Primary Target
Rac1
Target IC50: ~50 ?M against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
Reversible: yes
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Dwivedi, S., et al. 2010.J. Translational Med.8,128.
Desire, L., et al. 2005.J. Biol. Chem.280,37516.
Gao, Y., et al. 2004.Proc. Natl. Acad. Sci. USA101,7618.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C24H38Cl3N7 |
| 分子量 | 530.96 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥93% (HPLC) |
| 形式 | lyophilized |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 溶解性 | water: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
