半岛bd体育手机客户端 说明
一般描述
Cell-permeable, reversible, and competitive inhibitor of rat brain Ca+2/calmodulin-dependent protein kinase II (Ki= 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G1cell cycle arrest and apoptosis in NIH 3T3 cells.
A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki= 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G1cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 ?l) solution of KN-93 (Cat. No. 422712) in DMSO is also available.
包装
1, 5 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target Ki: 370 nM against rat brain CaM kinase II
Product competes with ATP.
Primary Target
cam kinase 2
Reversible: yes
警告
Toxicity: Irritant (B)
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
其他说明
Fan, G.H., et al. 1999.Mol. Pharmacol.56,39.
Tombes, R.M., et al. 1995.Cell Growth Differ.6,1063.
Mamiya, N., et al. 1993.Biochem. Biophys. Res. Commun.195,608.
Nicki, I., et al. 1993.Biochem. Biophys. Res. Commun.191,255.
Sumi, M., et al. 1991.Biochem. Biophys. Res. Commun.181,968.
Tokumitsu, H., et al. 1990.J. Biol. Chem.265,4315.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C27H29IN2O4S |
| 分子量 | 604.50 |
| MDL编号 | MFCD03788201 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+ |
| InChI key | LLLQTDSSHZREGW-AATRIKPKSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
