半岛bd体育手机客户端 说明
一般描述
Inhibitor of calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM), and cathepsin L (Ki= 500 pM). Inhibits neutral cysteine proteases and proteasome (Ki= 6 ?M). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.
Cell-permeable inhibitor of calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM), and cathepsin L (Ki= 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki= 6 ?M). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
包装
5, 25 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target Ki: 190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Product does not compete with ATP.
Reversible: no
Primary Target
Calpain-1
警告
Toxicity: Standard Handling (A)
序列
N-Acetyl-Leu-Leu-Nle-CHO
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Debiasi, R.L., et al. 1999.J. Virol.73,695.
Zhang, L., et al. 1999.J. Biol. Chem.274,8966.
Milligan, S.A., et al. 1996.Arch. Biochem. Biophys.335,388.
Griscavage, J.M., et al. 1995.Biochem. Biophys. Res. Commun.215,721.
Squier, M.K., et al. 1994.J. Cell Physiol.159,229.
Rami, J., and Kreiglstein, J. 1993.Brain Res.609,67.
Sherwood, S.W., et al. 1993.Proc. Natl. Acad. Sci.USA90,3353.
Vinitsky, A., et al. 1992.Biochemistry31,9421.
Sasaki, T., et al. 1990.J. Enzyme Inhib.3,195.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H37N3O4 |
| 分子量 | 383.53 |
| MDL编号 | MFCD00065505 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white to off-white |
| 溶解性 | DMSO: 10 mg/mL ethanol: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1 |
| InChI key | FMYKJLXRRQTBOR-BZSNNMDCSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
