半岛bd体育手机客户端 说明
一般描述
WGA is not blood group specific but has an affinity for N-acetyl-β-
Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface.
应用
Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.
Lectin fromTriticum vulgarishas been used in bone resorption assays.
生化/生理作用
Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.
其他说明
Molecular characteristics and specificity for sugar binding
基本信息
| MDL编号 | MFCD00147408 |
| NACRES | NA.56 |
半岛bd体育手机客户端 性质
| 生物来源 | Triticum vulgaris |
| 测定 | ≥55% (GE) |
| 形式 | powder |
| 质量 | lyophilized |
| technique(s) | agglutination assay: suitable using fresh human erythrocytes |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
