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位置: 首页> 品牌> Sigma-Aldrich> Purmorphamine-CAS 483367-10-8-Calbiochem

Purmorphamine-CAS 483367-10-8-Calbiochem

品牌
Sigma-Aldrich
CAS
483367-10-8
货号
540220
规格纯度
A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50= 1 μM).
价格
3299.37 *本价格含增值税费
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半岛bd体育手机客户端 名称:
483367-10-8
Purmorphamine-CAS 483367-10-8-Calbiochem
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50= 1 ?M) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 ?l) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC?? = 1 ?M).
A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC50= 1 ?M) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.

包装

5 mg in Plastic ampoule
20 mg in Glass bottle

生化/生理作用

Cell permeable: yes
Primary Target
Activation of the Hedgehog signaling pathway
Product does not compete with ATP.
EC50 = 1 ?M for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wu, X., et al. 2004.Chem. Biol.11,1229.
Wu, X., et al. 2002.J. Am. Chem. Soc.124,14520.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C31H32N6O2
分子量 520.62

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 200 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

象形图 GHS08
警示用语: Warning
危险声明 H341
预防措施声明 P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类 Muta. 2
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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