Antipain, Hydrochloride-CAS 37682-72-7-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC₅₀= 300 ?M).
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC₅₀~500 ng/ml). Effective at concentrations of 1-100 ?M.
Effective concentration: 1-100 ?M.

包装

10 mg in Plastic ampoule
5 mg in Glass bottle

生化/生理作用

Product does not compete with ATP.
Primary Target
Trypsin-like serine proteases
Reversible: no
Cell permeable: no
Target IC₅₀: 300 ?M against trypsin-like serine proteases, papain and some cysteine proteases

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

其他说明

Lyupina, Y.V., et al. 1996.Eur. J. Pharmacol.304,23.
Umezawa, H. 1976.Methods Enzymol.55,678.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C27H44N10O6· xHCl
分子量	604.70 (free base basis)
MDL编号	MFCD00135957

半岛bd体育手机客户端 性质

质量水平	100
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white to slightly yellowish
溶解性	water: 10 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
InChI key	GXQPAKIVOCLCHD-BXLPLHKWSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable