Thrombin Substrate, fluorogenic

半岛bd体育手机客户端 说明

Amino Acid Sequence

BOC-Val-Pro-Arg-AFC

一般描述

Thrombin has procoagulant and anticoagulant properties. It also has chemotactic and mitogenic effects. Thrombin triggers the growth of mammalian cells, fibroblasts and macrophage- like tumor cell lines. It regulates brain development. Thrombin plays an important role in hemostasis and thrombosis. It is associated with mast cell degranulation along with the release of histamine and enhances the production of IL-1 (interleukin-1) by activated macrophages. Thrombin stimulates vascular permeability and transendothelial cell migration by neutrophils.

应用

Thrombin is a serine protease involved in the coagulation cascade wherein it converts fibrinogen into fibrin. Thrombin may be detected (assayed) using peptides that contain the VPR sequence such as the fluorogenic substrates Boc-VPR-AFC, Boc-Val-Pro-Arg-7-AMC and the chromogenic substrate Boc-Val-Pro-Arg-pNA. These substrates may also be useful to detect other serine proteases.

基本信息

经验(实验)分子式	C31H42N7O7
分子量	624.71
NACRES	NA.32

半岛bd体育手机客户端 性质

测定	≥95% (HPLC)
形式	lyophilized
组成	Peptide Content, ≥80%
储存条件	protect from light
储存温度	?20℃