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Retinoblastoma protein human

品牌
Sigma-Aldrich
货号
SRP2081
规格纯度
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
价格
7915.99 *本价格含增值税费
促销
服务
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数量
- +
半岛bd体育手机客户端 名称:
Retinoblastoma protein human
p105-Rb
retinoblastoma 1
pp110
Rb
pRb
OSRC
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.

生化/生理作用

pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in insect cells
测定 ≥70% (SDS-PAGE)
形式 frozen liquid
分子量 ~107.5 kDa
包装 pkg of 5 μg
储存条件 avoid repeated freeze/thaw cycles
浓度 400 μg/mL
颜色 clear colorless
NCBI登记号 NM_000321
UniProt登记号 P06400
运输 dry ice
储存温度 ?70℃
Gene Information human ... RB1(5925)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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