ML-9

半岛bd体育手机客户端 说明

应用

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

包装

5 mg in glass bottle

生化/生理作用

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca₂⁺entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

特点和优势

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

线性分子式	C15H17N2O2SCl · HCl
分子量	361.29
MDL编号	MFCD00065525
PubChem化学物质编号	24278297
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥99% (TLC)
形式	powder
颜色	white
溶解性	ethanol: 10 mg/mL
储存温度	2-8℃
SMILES string	Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI	1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key	ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Gene Information	human ... SLC2A1(6513), SLC2A4(6517)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)