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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-MBP Antibody, clone P12

Anti-phospho-MBP Antibody, clone P12

品牌
Sigma-Aldrich
货号
05-429
规格纯度
clone P12, Upstate?, from mouse
价格
6202.75 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-MBP Antibody, clone P12
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system and has a molecular mass of 21.5 kDa. MBP is believed to be important in the process of myelination of nerves in the central nervous system (CNS). MBP was initially sequenced in 1979 after isolation from myelin membranes. Since that time, knockout mice deficient in MBP have been developed which showed decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death. The gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system.
The pool of MBP in the central nervous system is very diverse, with several splice variants being expressed and a large number of post-translational modifications on the protein, which include phosphorylation, methylation, deamidation and citrullination. MBP phosphorylation at Threonine 125 is a complex regulatory process that modulates the contribution of MBP to the stability of the Myelin sheath.
Interest in MBP has centered on its role in demyelinating diseases, particularly multiple sclerosis (MS). Several studies have shown a role for antibodies against MBP in the pathogenesis of MS. Some studies have linked a genetic predisposition to MS to the MBP gene, though a majority have not.

特异性

Recognizes MBP phosphorylated at Threonine 98; Some preparations of MBP contain basal levels of phosphorylated MBP, which are detected by the pMBP antibody.

免疫原

Synthetic peptide corresponding to the human myelin basic protein sequence phosphorylated at Thr98 and coupled to tuberculin

应用

Research Sub Category
MAP Kinases
Detect phospho-MBP using this Anti-phospho-MBP Antibody, clone P12 validated for use in EA & WB.
Research Category
Signaling

质量

routinely evaluated by immunoblot on MBP phosphorylated by MAP Kinase 2/Erk2, active (Catalog #14-173)

目标描述

33 kDa

外形

Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, PBS, and 0.09% sodium azide as a preservative.
Format: Purified
Protein A purified

储存及稳定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析说明

Control
Mouse brain extract or rat brain extract

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 P12, monoclonal
species reactivity vertebrates
manufacturer/tradename Upstate?
technique(s) activity assay: suitable
western blot: suitable
同位素/亚型 IgG
NCBI登记号 NM_002385
UniProt登记号 P02686
运输 dry ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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