半岛bd体育手机客户端 说明
一般描述
Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Meis1, 2, and 3 are members of the TALE (three amino acid loop extension) family of homeodomain containing proteins. Meis1 binds to Hox and Pbx proteins to form complexes with distinct DNA-binding specificities. Like Hox and Pbx proteins, the overexpression of Meis1 in BHX-2 myeloid leukemias implies a role for this protein in oncogenesis. Two Meis related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and express in normal tissues as well as myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.
特异性
Meis1, Meis2, Meis3 and splice variants
免疫原
MBP-conjugated fusion protein corresponding to amino acids 60-390 of mouse Meis1
应用
Research Sub Category
Transcription Factors
Research Category
Epigenetics & Nuclear Function
Detect Meis 1/2/3 with Anti-Meis 1/2/3 Antibody, clone 9.2.7 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB & IHC.
质量
routinely evaluated by immunoblot on nuclear extract from K562 cells
目标描述
Mr ~45-66kDa
联系
Replaces: MABN1071
外形
Ascites
mouse ascites IgG1 containing 0.05% sodium azide before the addition of glycerol to 30%
储存及稳定性
2 years at -20°C
分析说明
Control
K562 nuclear extract
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
生物来源 | mouse |
抗体形式 | ascites fluid |
antibody product type | primary antibodies |
克隆 | 9.2.7, monoclonal |
species reactivity | human, mouse |
manufacturer/tradename | Upstate? |
technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
同位素/亚型 | IgG1 |
NCBI登记号 | NM_170677 |
UniProt登记号 | O14770 |
运输 | dry ice |
Gene Information | human ... MEIS2(4212) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
Sigma-Aldrich