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位置: 首页> 品牌> Sigma-Aldrich> 6-keto-5α-hydroxycholesterol

6-keto-5α-hydroxycholesterol

品牌
Avanti
CAS
13027-33-3
货号
700140P
规格纯度
3β,5α-dihydroxy-cholestan-6-one, powder
价格
1861.99 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
13027-33-3
6-keto-5α-hydroxycholesterol
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

6-keto-5α-hydroxycholesterol, also known as 6-oxo-cholestan-3β,5α-diol (OCDO), is synthesized from the oxidation of 5β, 6β-epoxycholesterol in the presence of enzyme cholesterol epoxide hydrolase. It is also synthesized from cholestane-3β,5α,6β-triol by the enzyme 11β-hydroxysteroid dehydrogenase type II . The enzyme 11β-hydroxysteroid dehydrogenase type I catalyzes the reduction of OCDO to cholestane-3β,5α,6β-triol.

生化/生理作用

6-keto-5α-hydroxycholesterol favors tumor progression. cholestan-6-oxo-3β,5α-diolelicits cytotoxicity towards human bronchial 16-HBE cells and plays a key role in mediating cell necrosis post ozone exposure. It is an oncometabolite, which promotes breast cancer progression and also blocks chemotaxis mediated by polymorphonuclear leukocytes.

包装

5 mL Amber Glass Screw Cap Vial (700140P-5mg)

基本信息

经验(实验)分子式 C27H46O3
分子量 418.65
NACRES NA.25

半岛bd体育手机客户端 性质

测定 >99% (TLC)
形式 powder
包装 pkg of 1 × 5 mg (700140P-5mg)
manufacturer/tradename Avanti Polar Lipids 700140P
运输 dry ice
储存温度 ?20℃
InChI 1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,25-,26-,27+/m1/s1
InChI key SJZZRXMQSAXCFD-ZCBMJONGSA-N

安全信息

储存分类代码 13 - Non Combustible Solids

Sigma-Aldrich

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