Sulfuretin

半岛bd体育手机客户端 说明

一般描述

Sulfuretin is an aurones flavonoid found in the extract of Rhus verniciflua. The Extract of Rhus verniciflua is known in the traditional medicine and scientific community to have anti-cancer properties.Sulfuretin, one of the major constituents of Rhus verniciflua extract was found to have anti-cancer activities via activation of caspase-3 and inhibition of PARP. Moreover, sulfuretin downregulates cyclin D proteins by increasing the expression of miR-30C, a tumor suppressor micro RNA that is studied in regulation of cell proliferation.2 Structure-activity relationships (SAR) of Sulfuretin analogs inhibits the proliferation of leukemia cancer line panelin vitroandin vivoin zebrafish and mice models.Furthermore, Sulfuretin 100mg/Kgin vivostudy was beneficial in treating lymphoedema in mice.In addition, Sulfuretin has several other activities such as:

• Sulfuretin is an anti-adipogenic agent, suppressing the adipogenic factors C/EBPα, C/EBPβ and PPARγ, which are crucial regulators at the initial step of adipogenesis.
• Sulfuretin is a potent antioxidant which protects SH-SY5Y cell line from 6-OHDA induced ROS.
• Sulfuretin has antiviral activity through the inhibition of influenza virus neuraminidase in IC50 of 36μM.

生化/生理作用

Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory

基本信息

经验(实验)分子式	C15H10O5
分子量	270.24
MDL编号	MFCD00017304

半岛bd体育手机客户端 性质

描述	≥98% (HPLC)
质量水平	100
测定	≥98% (HPLC)
形式	solid
储存温度	2-8℃
SMILES string	OC1=CC=C2C(O/C(C2=O)=C\C3=CC(O)=C(O)C=C3)=C1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable