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sCD100 human

品牌
Sigma-Aldrich
货号
SRP3148
规格纯度
recombinant, expressed in CHO cells, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture
价格
4278.46 *本价格含增值税费
促销
服务
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数量
-+
半岛bd体育手机客户端 名称:
sCD100 human
GR3
Semaphorin-4D
A8
BB18
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The semphorins are a large family of phylogenetically conserved proteins that play a pivotal role in maintaining homeostasis in the immune system. Cluster of differentiation 100 (CD100), also known as semaphorin-4D (Sema-4D), is a 150kDa transmembrane class IV semaphorin. The CD100 precursor contains 862 amino acids, including a 21 amino acid signal sequence, a 713 amino acid extracellular domain, a 21 amino acid transmembrane sequence, and a 107 amino acid cytoplasmic region. The extracellular sequence contains several structural features, including a 479 amino acid "sema" domain, a 79 amino acid. Ig-like sequence and a 52 amino acid "Plexin-type repeat". The protein is expressed in a wide variety of tissues. Recombinant soluble CD100 is a 78.9kDa protein comprising the extracellular domain of CD100 (711 amino acids). SDS-PAGE analysis run under non-reducing conditions shows a mixture of disulfide linked dimer and monomer.

生化/生理作用

Studies have shown that cluster of differentiation 100 (CD100) can induce monocyte migration, T-cell activation, and B-cell survival, as well as T/B cell and T/DC "cooperation". CD100 inhibits the functions of osteoblasts and influences bone homeostasis in favor of resorption. The protein is overexpressed in epithelial malignancies and breast cancer.

序列

FAPIPRITWE HREVHLVQFH EPDIYNYSAL LLSEDKDTLY IGAREAVFAV NALNISEKQH EVYWKVSEDK KAKCAEKGKS KQTECLNYIR VLQPLSATSL YVCGTNAFQP ACDHLNLTSF KFLGKNEDGK GRCPFDPAHS YTSVMVDGEL YSGTSYNFLG SEPIISRNSS HSPLRTEYAI PWLNEPSFVF ADVIRKSPDS PDGEDDRVYF FFTEVSVEYE FVFRVLIPRI ARVCKGDQGG LRTLQKKWTS FLKARLICSR PDSGLVFNVL RDVFVLRSPG LKVPVFYALF TPQLNNVGLS AVCAYNLSTA EEVFSHGKYM QSTTVEQSHT KWVRYNGPVP KPRPGACIDS EARAANYTSS LNLPDKTLQF VKDHPLMDDS VTPIDNRPRL IKKDVNYTQI VVDRTQALDG TVYDVMFVST DRGALHKAIS LEHAVHIIEE TQLFQDFEPV QTLLLSSKKG NRFVYAGSNS GVVQAPLAFC GKHGTCEDCV LARDPYCAWS PPTATCVALH QTESPSRGLI QEMSGDASVC PDKSKGSYRQ HFFKHGGTAE LKCSQKSNLA RVFWKFQNGV LKAESPKYGL MGRKNLLIFN LSEGDSGVYQ CLSEERVKNK TVFQVVAKHV LEVKVVPKPV VAPTLSVVQT EGSRIATKVL VASTQGSSPP TPAVQATSSG AITLPPKPAP TGTSCEPKIV INTVPQLHSE KTMYLKSSDN R

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

半岛bd体育手机客户端 性质

生物来源human
重组expressed in CHO cells
测定≥97% (HPLC)
≥97% (SDS-PAGE)
形式lyophilized
分子量 78.9 kDa
包装pkg of 5 μg
technique(s)cell culture | mammalian: suitable
杂质<0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号Q92854
运输wet ice
储存温度−20℃
Gene Informationhuman ... SEMA4D(10507)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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