半岛bd体育手机客户端 说明
生化/生理作用
Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
基本信息
| NACRES | NA.26 |
半岛bd体育手机客户端 性质
| 生物来源 | human |
| 重组 | expressed in insect cells |
| 测定 | ≥80% (SDS-PAGE) |
| 形式 | frozen liquid |
| 分子量 | ~41.8 kDa |
| 包装 | pkg of 5 μg |
| 浓度 | 850 μg/mL |
| 颜色 | clear colorless |
| NCBI登记号 | NM_000546 |
| UniProt登记号 | P04637 |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
| Gene Information | human ... TP53(7157) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
