半岛bd体育手机客户端 说明
生化/生理作用
Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes. The core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function. Disruption or loss of oligomerization function is associated with loss of cell cycle arrest. This mutant protein (with the deletion of the C-terminus 51 residues including the entire basic domain and a portion of the tetramerization domain) can be used as a unique tool to study specific functions of p53 related to the C-terminus.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
基本信息
| NACRES | NA.26 |
半岛bd体育手机客户端 性质
| 生物来源 | human |
| 重组 | expressed in insect cells |
| 测定 | ≥80% (SDS-PAGE) |
| 形式 | frozen liquid |
| 分子量 | ~39.5 kDa |
| 包装 | pkg of 5 μg |
| 浓度 | 250 μg/mL |
| 颜色 | clear colorless |
| NCBI登记号 | NM_000546 |
| UniProt登记号 | P04637 |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
| Gene Information | human ... TP53(7157) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
