Monoclonal Anti-Paxillin antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.

特异性

Recognizes an epitope located in the LIM1 domain of the paxillin molecule.

免疫原

C-terminal part of recombinant chicken paxillin (amino acids 305-559)

应用

Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.

生化/生理作用

Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD00212475
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	ascites fluid
antibody product type	primary antibodies
克隆	PXC-10, monoclonal
分子量	antigen 68-40 kDa
包含	15 mM sodium azide
species reactivity	chicken, human, hamster, bovine, rat
technique(s)	immunocytochemistry: suitable microarray: suitable western blot: 1:500 using a cultured human cell line extract
同位素/亚型	IgG1
UniProt登记号	P49023
运输	dry ice
储存温度	?20℃
Gene Information	human ... PXN(5829) rat ... Pxn(360820)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable