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位置: 首页> 品牌> Sigma-Aldrich> Anti-TRF2 Antibody, clone 4A794

Anti-TRF2 Antibody, clone 4A794

品牌
Sigma-Aldrich
货号
05-521
规格纯度
clone 4A794, Upstate?, from mouse
价格
5529.94 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-TRF2 Antibody, clone 4A794
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis.

特异性

Recognizes TRF2.

免疫原

His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function
Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.

质量

routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate

目标描述

66 kDa

外形

Format: Purified
Protein G Purified mouse IgG1 in PBS with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析说明

Control
Positive Control Included: Jurkat cell lysate (12-303)

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 4A794, monoclonal
species reactivity human, rat
manufacturer/tradename Upstate?
technique(s) immunocytochemistry: suitable
western blot: suitable
同位素/亚型 IgG1
NCBI登记号 NM_005652
UniProt登记号 Q15554
运输 dry ice
Gene Information human ... TERF2(7014)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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