Thymidine Phosphorylase, recombinant fromEscherichia coli

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包装

5000 units in glass bottle

生化/生理作用

An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. TheE. colithymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purifiedE. colienzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays.

单位定义

One unit will convert 1.0 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per min at pH 7.4 at 25℃.

制备说明

Cloned fromE. coliand produced in overexpressingE. coli

基本信息

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安全信息