半岛bd体育手机客户端 说明
一般描述
Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.
Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21rasby insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
其他说明
Rao, S., et al. 1999.Proc. Natl. Acad. Sci. USA96,7197.
Carel, K., et al. 1996.J. Biol. Chem.271,30625.
McGuire, T.F., et al. 1996.J. Biol. Chem.271,27402.
Umetani, N., et al. 1996.Biochim. Biophys. Acta1303,199.
Xu, X.Q., et al. 1996.Arch. Biochem. Biophys.326,233.
Reusch, J.E.-B., et al. 1995.J. Biol. Chem.270,2036.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C24H37O6· Na |
| 分子量 | 444.54 |
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | off-white |
| 溶解性 | DMSO: 100 mg/mL ethanol: 50 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
