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Interleukin-11 human

品牌
Sigma-Aldrich
货号
I2406
规格纯度
>97% (SDS-PAGE), recombinant, expressed in baculovirus infectedSf21 cells, lyophilized powder, suitable for cell culture
价格
4609.27 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Interleukin-11 human
IL-11
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes.
The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein.

生化/生理作用

Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.

外形

Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.

分析说明

The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.

基本信息

MDL编号 MFCD00212208
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 100
生物来源 human
重组 expressed in baculovirus infectedSf21 cells
测定 >97% (SDS-PAGE)
形式 lyophilized powder
效能 0.06-0.24 ng/mL ED50
分子量 23 kDa
包装 pkg of 5 μg
technique(s) cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号 P20809
储存温度 ?20℃
Gene Information human ... IL11(3589)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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