半岛bd体育手机客户端 说明
一般描述
A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50<1 ?M) in cardiomyocytes, and ameliorate insulin resistance in KKAymice by regulating adiponectin release.
A cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC50~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50<1 ?M) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKAymice by regulating adiponectin release.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
IKK-2
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 250 nM blocking IκBα phosphorylation
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Kamon, J., et al. 2004.Biochem. Biophys. Res. Commun.323,242.
Onai, Y., et al. 2004.Cardiovasc. Res.63,51.
Tanaka, A., et al. 2004.Blood105,2324.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H8ClF6NO2 |
| 分子量 | 383.67 |
| MDL编号 | MFCD00218820 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | ethanol: 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
