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Rolipram-CAS 61413-54-5-Calbiochem

品牌
Sigma-Aldrich
CAS
61413-54-5
货号
557330
规格纯度
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50= 800 nM).
价格
2950.71 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
61413-54-5
Rolipram-CAS 61413-54-5-Calbiochem
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50= 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
Cell permeable, selective competitive inhibitor of cAMP-specific phosphodiesterase IV (IC50= 800 nM). Rolipram does not inhibit PDE I or PDE II, even at concentrations as high as 100 ?M. It is only a weak inhibitor of PDE III (IC50= 100 ?M). A rolipram-insensitive phosphodiesterase IV subtype is also known to exist.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
PDE IV
Product does not compete with ATP.
Reversible: no
Target IC50: 800 nM against cAMP-specific phosphodiesterase (PDE IV)

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.

其他说明

Navarro, J., et al. 1998.J. Virol.72,4712.
Truong, V.H. and Muller, T. 1994.FEBS Lett.353,113.
Underwood, D.C., et al. 1994.J. Pharmacol. Exp. Ther.270,250.
Moore, J.B., Jr., et al. 1991.Biochem. Pharmacol.42,679.
Reeves, M.L., et al. 1987.Biochem. J.241,535.
Schneider, H.H., et al. 1986.Eur. J. Pharmacol.127,105.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C16H21NO3
分子量 275.34
MDL编号 MFCD00270906

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
颜色 white
溶解性 DMSO: soluble
运输 ambient
储存温度 2-8℃
InChI 1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
InChI key HJORMJIFDVBMOB-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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