Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor-CAS 509093-47-4-Calbiochem

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一般描述

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀= 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀>10 ?M), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀= 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀>10 ?M), including lck and src.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Interleukin-1 receptor-associated kinases
Target IC₅₀: 300 nM and 200 nM for IRAK-1 and -4
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Harmful (C)

其他说明

Bhattacharyya, S., et al. 2007.Am. J. Physiol. Gastrointest. Liver Physiol.293,G429.
Powers, J.P., et al. 2006.Bioorg. Med. Chem. Lett.16,2842.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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