TOFA-CAS 54857-86-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀= 4 ?M in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
A cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀= 4 ?M in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Acetyl-CoA carboxylase (ACC)
Target IC₅₀: 4 ?M inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
Reversible: yes
Cell permeable: yes
Product competes with ATP.

警告

Toxicity: Carcinogenic / Teratogenic (D)

制备说明

Slight warming and sonication may be required for complete solubilization in ethanol.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Landree, L.E., et al. 2004.J. Biol. Chem.279,3817.
Zhou, W., et al. 2003.Cancer Res.63,7330.
Hu, Z., et al. 2003.Proc. Natl. Acad. Sci. USA100,12624.
Pizer, E.S., et al. 2000.Cancer Res.60,213.
Arbeeny, C.M., et al. 1992.J. Lipid Res.33,843.
Fukuda, N. and Ontko, J.A. 1984.J. Lipid Res.25,831.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C19H32O4
分子量	324.45
MDL编号	MFCD01726059

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 10 mg/mL ethanol: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
InChI key	CZRCFAOMWRAFIC-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable