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位置:首页 > 品牌 > Sigma-Aldrich > TMEM16A Inhibitor, T16Ainh-A01-Calbiochem

TMEM16A Inhibitor, T16Ainh-A01-Calbiochem

品牌
Sigma-Aldrich
CAS
552309-42-9
货号
613551
规格纯度
The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.
价格
2985.99 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
半岛bd体育手机客户端 名称:
552309-42-9
TMEM16A Inhibitor, T16Ainh-A01-Calbiochem
ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Davis, A.J., et al. 2012 Br. J. Pharmacol.,in press
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H20N4O3S2
分子量416.52
MDL编号MFCD03278952

半岛bd体育手机客户端 性质

质量水平100
测定≥97% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 100 mg/mL, clear, colorless
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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