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Sodium Salicylate-CAS 54-21-7-Calbiochem

品牌
Sigma-Aldrich
CAS
54-21-7
货号
567630
规格纯度
A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.
价格
773.29 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
54-21-7
Sodium Salicylate-CAS 54-21-7-Calbiochem
Salicylic Acid, Na, NaSal
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

包装

5 g in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Schwenger, P., et al. 1998.Mol. Cell. Biol.18,78.
Mitchell, J.A., et al. 1997.Mol. Pharmacol.51,907.
Schwenger, P., et al. 1997.Proc. Natl. Acad. Sci. USA94,2869.
Farivar, R.S. and Brecher, P. 1996.J. Biol. Chem.271,31585.
Schwenger, P., et al. 1996.J. Biol. Chem.271,8089.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C7H5O3· Na
分子量 160.10
MDL编号 MFCD00002440

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (titration)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 off-white
溶解性 water: 50 mg/mL
ethanol: soluble
运输 ambient
储存温度 10-30℃
InChI 1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI key ABBQHOQBGMUPJH-UHFFFAOYSA-M

安全信息

象形图 GHS07GHS08
警示用语: Warning
危险声明 H302 - H319 - H361d
预防措施声明 P201 - P202 - P264 - P301 + P312 - P305 + P351 + P338 - P308 + P313
危险分类 Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) 208.9 °F - Pensky-Martens closed cup
闪点(C) 98.3 ℃ - Pensky-Martens closed cup

Sigma-Aldrich

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