Sirtinol-CAS 410536-97-9-Calbiochem

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一般描述

A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1 (IC₅₀= 48 ?M, 131 ?M and 58 ?M for ySir2, hSIRT1 and hSIRT2, respectively). Reported to inhibit Sir2p transcriptional silencing activityin vivo(IC₅₀= 25 ?M), and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p and human SIRT2in vitro(IC₅₀= 70 ?M and 40 ?M, respectively). A 10 mM (1 mg/254 ?l) solution of Sirtinol (Cat. No. 566321) in DMSO is also available.
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activityin vivo(IC₅₀= 25 ?M) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2in vitro(IC₅₀= 68 ?M and 38 ?M, respectively).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Human HDAC1
Target IC₅₀: 48 ?M, 131 ?M and 58 ?M for ySir2, hSIRT1 and hSIRT2
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Mai, A., et al. 2005.J. Med. Chem.48,7789.
Grozinger, C.M., et al. 2001.J. Biol. Chem.276,38837.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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