Polo-like Kinase Inhibitor V, Poloxin-CAS 321688-88-4-Calbiochem

品牌

Sigma-Aldrich

CAS

321688-88-4

货号

528884

包装型号

5 MG, The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylat

规格纯度

The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

2340.22 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

321688-88-4
Polo-like Kinase Inhibitor V, Poloxin-CAS 321688-88-4-Calbiochem
Polo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC₅₀) = 4.8 ?M. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 ?M. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Reindl, W., et al. 2008.Chem Biol.15,459.
Yuan, J., et al. 2011,Am J Pathol179,2091.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₈H₁₉NO₃
分子量	297.35
MDL编号	MFCD00534351

半岛bd体育手机客户端性质

质量水平	100
测定	≥99% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 25 mg/mL, clear, yellow
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3