半岛bd体育手机客户端 说明
一般描述
A cell-permeable pyridinecarbonitrile compound that acts as a potent, ATP-competitive (Ki= 79 nM, using PKCθ KD in coupled PK/LDH assays), and isozyme-selective PKCθ inhibitor (IC50= 70 nM) with much reduced potency against other novel PKCs (IC50= 0.35, 2.33, and 16.35 ?M against δ, ε, and η isoforms, respectively) and little or no activity against the conventional PKCβ and atypical PKCζ (IC50>50 ?M) as well as a panel of 18 other commonly studied cellular kinases (IC50>10 ?M). Shown to preferentially inhibit IL-2 production from anti-CD3- and anti-CD28-activated T cells derived from wild-type over PKCθ-knockout mice (IC50= 58 and 231 nM, respectively).
包装
5 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Cole, D.C., et al. 2008.J. Med. Chem.51,5958.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C22H18N4O2 |
| 分子量 | 370.40 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | light yellow |
| 溶解性 | ethanol: 1 mg/mL DMSO: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
