PI 3-Kα Inhibitor IV-CAS 1188890-32-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-Ks (IC₅₀= 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC₅₀≥ 3.4 ?M for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC₅₀= 580 nM) and serum-stimulated Akt phosphorylation (IC₅₀<3 ?M) in A375 melanoma cells.
A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC₅₀= 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC₅₀≥3.4 ?M for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC₅₀= 580 nM) and serum-stimulated Akt phosphorylation (IC₅₀<3 ?M) in A375 melanoma cells.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
PI 3-Kα
Target IC₅₀: 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Hayakawa, M., et al. 2006.Bioorg. Med. Chem.14,6847.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C16H15N3O2S · 2HCl
分子量	386.30

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	off-white
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable