半岛bd体育手机客户端 说明
一般描述
A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E2) production by inhibiting COX-1 and mPGES-1 (microsomal PGE2synthase-1), but not COX-2, activity (IC50= 8, 2, and 58 M, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat. No. 437996) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (<10% by 1 M MK-886). Unlike NSAIDs (nonsteroidal antiinflammatory drugs) that target only COX pathway, MK-886 does not cause gastrointestinal damages when appliedin vivo.
包装
5 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
leukotreine biosybthesis
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
其他说明
Koeberle, A., et al. 2009.Eur. J. Pharmacol.608,84.
Koeberle, A., et al. 2008.J. Pharmacol. Exp. Ther.326,975.
Fisher, L., et al. 2007.Br. J. Pharmacol.152,471.
Ford-Hutchinson, A.W., et al. 1993.Can. J. Physiol. Pharmacol.71,806.
Ford-Hutchinson, A.W. 1991.Trends Pharmacol.12,68.
Dixon, R.A., et al. 1990.Nature343,282.
Rouzer, C.A., et al. 1990.J. Biol. Chem.265,1436.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C27H33ClNO2S · Na |
| 分子量 | 494.06 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥99% (TLC) |
| 形式 | solid |
| 效能 | 102 nM IC50 |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | DMSO: 25 mg/mL ethanol: 25 mg/mL |
| 运输 | ambient |
| 储存温度 | 10-30℃ |
| InChI | 1S/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31) |
| InChI key | VFMGWQLOCZBFCK-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
