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位置: 首页> 品牌> Sigma-Aldrich> MEK1/2 Inhibitor III-CAS 391210-10-9-Calbiochem

MEK1/2 Inhibitor III-CAS 391210-10-9-Calbiochem

品牌
Sigma-Aldrich
CAS
391210-10-9
货号
444966
规格纯度
The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
2950.71 *本价格含增值税费
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半岛bd体育手机客户端 名称:
391210-10-9
MEK1/2 Inhibitor III-CAS 391210-10-9-Calbiochem
PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 ?M in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumorin vivo. Also available in InSolution format (Cat. No. 444968).
A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 ?M in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumorin vivo.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Barrett, S.D., et al. 2008.Bioorg. Med. Chem. Lett.18,6501.
Leyton, J., et al. 2008.Mol. Cancer Ther.7,3112.
Silva, J., et al. 2008.PLoS Biol.6,2237.
Ying, Q.L., et al. 2008.Nature453,519.
Bain, J., et al. 2007.Biochem. J.408,297.
Solit, D.B., et al. 2006.Nature439,358.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C16H14F3IN2O4
分子量 482.19
MDL编号 MFCD08435926

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white to off-white
溶解性 DMSO: 20 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

象形图 GHS06GHS08
警示用语: Danger
危险声明 H301 - H373 - H413
预防措施声明 P260 - P264 - P270 - P273 - P301 + P310 - P314
危险分类 Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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