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LDN-211904-Calbiochem

品牌
Sigma-Aldrich
货号
428201
规格纯度
LDN-211904 modulates the biological activity of EphB3 receptor tyrosine kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
3352.28 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
LDN-211904-Calbiochem
N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate, EphB3 inhibitor, LDN-211904
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 ?M in cells. When profiled against a panel of 288 kinases at 5 ?M, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38β, and Qik.

包装

5 mg in Glass bottle

生化/生理作用

Cell permeable: yes
Primary Target
Erythropoietin-producing hepatocellular carcinoma (Eph)
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Qiao, L., et al. 2011,Bioorg. Med. Chem. Lett.19,6122

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C21H21ClN4O5
分子量 444.87
MDL编号 MFCD28023573

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥99% (HPLC)
形式 solid
效能 79 nM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 50 mg/mL, clear, nearly colorless
运输 ambient
储存温度 2-8℃
SMILES string O=C(NC1=CC=CC=C1Cl)C2=CN=C3C=CC(C4CCNCC4)=CN32.OC(C(O)=O)=O

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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