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位置: 首页> 品牌> Sigma-Aldrich> Kir2.1 Inhibitor, ML133-CAS 185669-79-8-Calbiochem

Kir2.1 Inhibitor, ML133-CAS 185669-79-8-Calbiochem

品牌
Sigma-Aldrich
CAS
185669-79-8
货号
422689
规格纯度
The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.
价格
1954.93 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
185669-79-8
K ir2.1 Inhibitor, ML133-CAS 185669-79-8-Calbiochem
Inward rectifier potassium channel blocker, ML133
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50= 1.8 ?M and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50>300 ?M) and displays weak activity for Kir4.1 and Kir7.1 (IC50= 76 ?M and 33 ?M, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lindsley, C.W., et al. 2011.ACS Chem. Biol.6,845.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C19H19NO
分子量 277.36
MDL编号 MFCD01469095

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 10 mg/mL, clear, colorless
运输 ambient
储存温度 2-8℃
SMILES string COC(C=C1)=CC=C1CNCC2=C(C=CC=C3)C3=CC=C2

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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