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JNK Inhibitor IX-CAS 312917-14-9-Calbiochem

品牌
Sigma-Aldrich
CAS
312917-14-9
货号
420136
规格纯度
The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
3124.36 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
312917-14-9
JNK Inhibitor IX-CAS 312917-14-9-Calbiochem
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50= 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC50= 6.4 and 5.9, respectively) under the same assay conditions.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
JNK2 and JNK3
Reversible: no
Product competes with ATP.
pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Angell, R.M., et al. 2007.Bioorg. Med. Chem. Lett.17,1296.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C20H16N2OS · xH2O
分子量 332.42 (anhydrous basis)

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 tan
溶解性 DMSO: 10 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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