InSolution U0126-CAS 109511-58-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent and specific inhibitor of MEK1 (IC₅₀= 72 nM) and MEK2 (IC₅₀= 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z),E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 100 mM (5 mg/124 ?l) solution of U0126 (Cat. No. 662005) in DMSO.

重悬

Following initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).

其他说明

Duncia, J.V., et al. 1998.Bioorg. Med. Chem. Lett.8,2839.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C18H16N6S2· 0.5C2H6O
分子量	403.52

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
运输	ambient
储存温度	?70℃
InChI	1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChI key	DVEXZJFMOKTQEZ-JYFOCSDGSA-N