半岛bd体育手机客户端 说明
一般描述
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available.
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.
包装
5 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Reversible: yes
警告
Toxicity: Irritant (B)
外形
A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H?O.
重悬
Following initial thaw, aliquot and freeze (-70°C).
其他说明
Yada, T., et al. 1999.Br. J. Pharmacol.126,1205.
Clutterbuck, R.D., et al. 1998.Br. J. Haematol.102,522.
Yokoyama, K., et al. 1998.Mol. Biochem. Parasitol.94,87.
Negre-Aminou, P., et al. 1997.Biochim. Biophys. Acta1345,259.
Vrtovsnik, F., et al. 1997.Kidney Int.52,1016.
Keyomarsi, K., et al. 1991.Cancer Res.51,3602.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C25H39O6· Na |
| 分子量 | 458.56 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| 运输 | ambient |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
