半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50= 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
Primary Target
JNK 1, JNK 2, JNK 3
Product competes with ATP.
Reversible: yes
警告
Toxicity: Irritant (B)
外形
A 50 mM (5 mg/454 ?l) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
重悬
Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
其他说明
Bennett, B.L., et al. 2001.Proc. Natl. Acad. Sci. USA98,13681.
Han, Z., et al. 2001.J. Clin. Invest.108,73.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C14H8N2O |
| 分子量 | 220.23 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | yellow-brown |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
