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位置: 首页> 品牌> Sigma-Aldrich> InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

品牌
Sigma-Aldrich
CAS
315706-13-9
货号
324519
包装型号
规格纯度
价格
2165.23 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
315706-13-9
InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem
eIF4F Inhibitor I, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid
2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD= 25 ?M) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xLin Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50~25 ?M). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours inEif4ebp2knockout mice.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
eIF4E

警告

Toxicity: Irritant (B)

外形

A 25 mM (5 mg/443 ?L) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他说明

Gkogkas, C.G., et al. 2012.Nature493,371.
Moerke, N. J., et al. 2007.Cell128,257.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C18H12Cl2N4O4S
分子量 451.28

半岛bd体育手机客户端 性质

测定 ≥95% (sum of two isomers, HPLC)
质量水平 100
形式 liquid
效能 25 μM Ki
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输 dry ice
储存温度 ?70℃

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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