ILK inhibitor, Cpd 22-Calbiochem

品牌

Sigma-Aldrich

货号

407331

包装型号

5 MG, The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

规格纯度

The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

2566.78 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

ILK inhibitor, Cpd 22-Calbiochem

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC₅₀= 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC₅₀= 1 to 2.5 mM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC₅₀= 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC₅₀= 1 to 2.5 ?M) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lee, S., et al. 2011.J. Med. Chem.54,6364

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₃₀H₃₀F₃N₅O
分子量	533.59

半岛bd体育手机客户端性质

质量水平	100
测定	≥94% (HPLC)
形式	powder
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable