Histone Deacetylase Inhibitor II-CAS 174664-65-4-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 ?M). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma cells, which can be blocked by Caspase Inhibitor Z-VAD-FMK (Cat. No. 627610).
A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 ?M). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
HDAC
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Coffey, D.C., et al. 2001.Cancer Res.61, 3591.
Coffey, D.C., et al. 2000.Pediatr. Oncol.35, 577.
Marks, P.A., et al. 2000.J. Natl. Cancer Inst.92, 1210.
Glick, R.D., et al. 1999.Cancer Res.59, 4392.
Richon, V.M., et al. 1998.Proc. Natl. Acad. Sci. USA95, 3003.
Richon, V.M., et al. 1996.Proc. Natl. Acad. Sci. USA93, 5705.

法律信息

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C10H10N2O4
分子量	222.20

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable