γ-Secretase Inhibitor XII-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activityin vitro(Aβ₄₀IC₅₀= 7.9 ?M; Aβ₄₂IC₅₀= 7.6 ?M) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ₄₀IC₅₀= 11.5 ?M; Aβ₄₂IC₅₀= 8.3 ?M). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
A cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activityin vitro(Aβ₄₀IC₅₀= 7.9 ?M; Aβ₄₂IC₅₀= 7.6 ?M) and in cultured cells that stably over-express APP695 (Aβ₄₀IC₅₀= 11.5 ?M; Aβ₄₂IC₅₀= 8.3 ?M). Also shown to block the generation of γCTF (γ-secretase-generated carboxy-terminal fragment).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 7.9 ?M for Aβ40; 7.6 ?M for Aβ42in vitro
Product does not compete with ATP.
Reversible: yes
Primary Target
Aβ40in vitro

警告

Toxicity: Standard Handling (A)

序列

Z-Ile-Leu-CHO

其他说明

Weijzen, S., et al. 2002.Nat. Med.8,979.
McLendon, C., et al. 2000.FASEB J.14,2383.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C20H30N2O4
分子量	362.46

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable