Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC₅₀= 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca²⁺]_iincrease, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 ?M. Also inhibits Aβ₄₂peptide-induced superoxide generation and prevents its internalization in human macrophages.
A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC₅₀= 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca²⁺]_iincrease, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 ?M. Further, inhibits Aβ₄₂peptide-induced superoxide generation and prevents its internalization in human macrophages.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)
Target IC₅₀: 230 nM for FPRL1 Agonist
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

H-Trp-Arg-Trp-Trp-Trp-Trp-CONH?

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Bae, Y.S., et al. 2004.J. Immunol.173,607.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C61H65N15O6
分子量	1104.27

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable