Formyl Peptide Receptor-Like 1 Agonist, WKYMVm-Calbiochem

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一般描述

A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀= 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g.NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca²⁺] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀= 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g.NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
Product does not compete with ATP.
Reversible: no
Primary Target
Formyl Peptide Receptor-Like 1
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

H-Trp-Lys-Tyr-Met-Val-D-Met-CONH?

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Bae, Y.S., et al. 2004.J. Immunol.173,607.
Bae, Y.S., et al. 2003.Mol. Pharmacol.64,841.
Le, Y., et al. 1999.J. Immunol.163,6777.
Seo, J.K., et al. 1997.J. Immunol.158,1895.
Baek, S.H., et al. 1996.J. Biol. Chem.271,8170.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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