您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> D609, Potassium Salt-CAS 83373-60-8-Calbiochem

D609, Potassium Salt-CAS 83373-60-8-Calbiochem

品牌
Sigma-Aldrich
CAS
83373-60-8
货号
251400
规格纯度
Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki= 5-10 μM).
价格
3736.22 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
83373-60-8
D609, Potassium Salt-CAS 83373-60-8-Calbiochem
Tricyclodecan-9-yl-xanthogenate, K
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki= 5-10 ?M). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki= 5-10 ?M). Does not inhibit (up to 50 ?M) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

包装

5 mg in Plastic ampoule

生化/生理作用

Primary Target
pc-specificphopholipase c
Product does not compete with ATP.
Reversible: no
Target Ki: 5-10 ?M against phosphatidylcholine (PC)-specific phospholipase C
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

重悬

Material is very labile once in solution (1.5 day half-life in tissue culture medium).

其他说明

Monick, M.M., et al. 1999.J. Immunol.162,3005.
Lozanski, G., et al. 1997.Biochem. J.328,271.
Maragoudakis, M.E., et al. 1993.Kidney Int.43,147.
Doppler, C., et al. 1992.AIDS Res. Human Retroviruses8,245.
Schutze, S., et al. 1992.Cell71,765.
Sauer, G., et al. 1990.Cancer Lett.53,97.
Muller-Decker, K. 1989.Biochem. Biophys. Res. Commun.162,198.
Amtmann, E., et al. 1987.Biochem. Pharmacol.36,1545.
Sauer, G., et al. 1984.Proc. Natl. Acad. Sci. USA81,3263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C11H15OS2· K
分子量 266.46
MDL编号 MFCD00171401

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 off-white
溶解性 DMSO: 25 mg/mL
water: 25 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);
InChI key YFUFHKMDCZBHMY-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map