D-erythro-Sphingosine, N-Hexanoyl--CAS 124753-97-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G₀/G₁phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
Biologically active, cell-permeable, nonphysiological ceramide analog. Stimulates cytosolic serine/threonine protein phosphatase in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. Induces a dramatic arrest in the G_o/G₁phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis in Molt-4 leukemia cells.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
Primary Target
MAP kinase, protein phosphatase 2A (PP2A)

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Jayadev, S., et al. 1995.J. Biol. Chem.270,2047.
Venable, M.E., et al. 1994.J. Biol. Chem.269,26040.
Dobrowsky, R.T., et al. 1993.J. Biol. Chem.268,15523.
Raines, M.A., et al. 1993.J. Biol. Chem.268,14572.
Dobrowsky, R.T., and Hannun, Y.A. 1992.J. Biol. Chem.267,5048.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C24H47NO3
分子量	397.63
MDL编号	MFCD00870174

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (TLC)
形式	waxy solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	white
溶解性	ethanol: 25 mg/mL DMSO: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
InChI key	NPRJSFWNFTXXQC-VHEBQXMUSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable