半岛bd体育手机客户端 说明
一般描述
A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+exchanger (IC50= 360 nM). Enhances the export of Ca2+from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+channels.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 360 nM against mitochondrial Na+/Ca2+ exchanger
Product does not compete with ATP.
Reversible: no
Primary Target
Mitochondrial Na+/Ca2+ exchanger
警告
Toxicity: Standard Handling (A)
制备说明
Dilute in Ca2+-free buffer just prior to use.
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Jornot, L., et al. 1999.J. Cell Sci.112,1013.
Babcock, D.F., et al. 1997.J. Cell Biol.136,833.
Baron. K.T., and Thayer, S.A. 1997.Eur. J. Pharmacol.340,295.
Griffiths, E.J., et al. 1997.Cell Calcium21,321.
White, R.J., and Reynolds, I.J. 1996,J. Neurosci.16,5688.
Cox, D.A., et al. 1993.J. Cardivasc. Pharmacol.21,595.
Cox, D.A., and Matlib, M.A. 1993.J. Biol. Chem.268,938.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H11Cl2NOS |
| 分子量 | 324.22 |
| MDL编号 | MFCD09055422 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19) |
| InChI key | KQEPIRKXSUIUTH-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
