半岛bd体育手机客户端 说明
一般描述
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
A cell-permeable and irreversible inhibitor of caspase-1 (Ki= 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
包装
5 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target Ki: 760 pM against caspase-1
Product does not compete with ATP.
Reversible: no
Primary Target
caspase-1
警告
Toxicity: Standard Handling (A)
序列
Ac-Tyr-Val-Ala-Asp-CMK
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Brenner, B., et al. 1998.Cell Death Differ.5,29.
Garcia-Calvo, M., et al. 1998.J. Biol. Chem.273,32608.
Hilbi, H., et al. 1998.J. Biol. Chem.273,32895.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
Schlegel, J., et al. 1996.J. Biol. Chem.271,1841.
Enari, M., et al. 1995.Nature375,78.
Walker, N.P.C., et al. 1994.Cell78,343.
Thornberry, N., et al. 1992.Nature356,768.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C24H33ClN4O8 |
| 分子量 | 540.99 |
| MDL编号 | MFCD00237124 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated |
| 颜色 | white |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
