Bcl-2 Inhibitor II, YC137-CAS 810659-53-1-Calbiochem

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一般描述

A cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (<300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-x_L-dependent cells, even at a concentration of 5 ?M. Preferentially binds Bcl-2 (K_i= 1.3 ?M) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochromecfrom mitochondria and activate caspase-9.
A cell-permeable molecule that targets the BH3?domain interaction and selectively induces apoptosis in Bcl-2-overexpressing cells (<300 nM in MDA-MB435B breast cancer cells). Exhibits little effect on a variety of primary cells and Bcl-x_L-dependent cells, even at a concentrations as high as 5 ?M. Inhibits the binding of Bid BH3 to Bcl-2 thereby blocking the anti-apoptotic activity of Bcl-2.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target K_i: 1.3 ?M in binding Bcl-2

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Real, P.J., et al. 2004.Cancer Res.64, 7947.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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